Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome
نویسندگان
چکیده
Introduction Sodium channel blockade (SCB) with a class Ia or Ic antiarrhythmic agent (eg, ajmaline or procainamide, respectively) is used in the unmasking and diagnosis of Brugada syndrome (BrS). SCB is performed frequently as part of family screening or in symptomatic patients with a suggestive electrocardiogram (ECG), and concurrent medications known to potentiate arrhythmias or contraindicated in BrS are withheld prior to testing. Lamotrigine (LTG) is currently not contraindicated in BrS or known to be potentially arrhythmic during testing with SCB agents. We report a case illustrating its arrhythmogenic potential and the implications of its concurrent usage during such testing in clinical practice.
منابع مشابه
The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol.
AIMS The diagnostic ECG pattern in Brugada syndrome (BS) can transiently normalize and may be unmasked by sodium channel blockers such as ajmaline. Proarrhythmic effects of the drug have been well documented in the literature. A detailed protocol for the ajmaline challenge in Brugada syndrome has not yet been described. Therefore, we prospectively studied the risks of a standardized ajmaline te...
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